From Cancun International Airport:

Travel south in Highway 307 through Playa Del Carmen.
When you reach Tulum, drive until you reach a set of traffic lights where you will
notice the Super San Francisco supermarket and car park and the Hertz Car
Rental sign on your right side. 
Turn left at these lights and take this road to the end (approximately 3km) and
you will come to a ‘T’ intersection.
Turn left and drive 1.5km to Mezzanine.
The driving time from Cancun Airport to Mezzanine is approximately 1.5 hours.